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Starting from 3 RPVCs designated from KFDA (now, MFDS) in 2006, the number of centers gradually increased to 6 in 2007 and to 9 in 2008. By 2011, it increased to 20 centers through Pharmacovigilance Research Network (PVNet).
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Starting from 2012, the Korea Institute of Drug Safety and Risk Management (KIDS) has taken the role of central center that manages all RPVCs - 22 RPVCs in 2013, and 27 RPVCs in 2019
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Since 2020, With the new RPVC for Korean Herbal Medicines, KIDS manages a totla of 28 RPVCs.