Development of DUR Criteria

국민의 안전과 건강을 지키는 한국의약품안전관리원

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  1. 1. How is it developed?

    The DUR criteria development process is shown below. Target drugs are selected based on the clinical use and significance, and their drug label information is reviewed. Additional review of clinical guidelines and further literature review is performed. Based on the collected information and expert opinions, KIDS submit the final conclusion to MFDS.


    Assessment of DUR Information


    We also evaluate current use of the target drugs to examine the actual usage in patients and how they are clinically significant especially in terms of adverse drug reactions. Korea Adverse Event Reporting System (KAERS) database and other claims data from various sources are used for analysis.

    Steps of DUR information review

    KIDS evaluate and develop DUR criteria both regularly and in as-needed basis. Regular evaluation is done for frequently prescribed drugs, drugs with safety issues, and drugs requiring interventions. This is evaluated and updated regularly. Special evaluation is done when clinicians submit suggestions regarding DUR criteria change or further examination of previous criteria.

  2. 2. Types of DUR Criteria


    Current DUR criteria

  3. 3. Current status of DUR information

    (as of 2017.12.31)

    Types of information No.
    Contraindicated Drugs Drug-Drug Interaction 946
    Age Contraindication: Pediatrics 160
    Contraindication during Pregnancy 700
    Drugs to be used with caution Therapeutic Duplication 328
    Incorrect drug dosage 219
    Incorrect duration of drug treatment 16
    Drugs to be used cautiously in the elderly 20
    Medication deferral list for blood donation 7
    Drugs that require caution in splitting 24